What is renal cell carcinoma

Renal Cell Cancer Treatment (PDQ®)–Patient Version

what is renal cell carcinoma

Renal cell carcinoma (RCC) is also called hypernephroma, renal adenocarcinoma, or renal or kidney cancer. It's the most common kind of.

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Renal cell carcinoma RCC is also called hypernephroma, renal adenocarcinoma, or renal or kidney cancer. The kidneys are organs in your body that help get rid of waste while also regulating fluid balance. There are tiny tubes in the kidneys called tubules. These help filter the blood, aid in excreting waste, and help make urine. RCC occurs when cancer cells start growing uncontrollably in the lining of the tubules of the kidney.

Renal cell cancer also called kidney cancer or renal cell adenocarcinoma is a disease in which malignant cancer cells are found in the lining of tubules very small tubes in the kidney.
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Renal cell carcinoma RCC is the most common type of kidney cancer. The cancerous cells typically develop in the lining of very small tubes in the kidney, called tubules. Over time, these cells may grow into a mass and cause an obstruction. The cancer may form in one or both kidneys. Clear cell RCC accounts for approximately 80 percent of all renal cell carcinomas. The tumor cells appear very pale or clear when observed under a microscope. The cancerous cells develop finger-like projections in the tumor.

Renal cell carcinoma RCC is a kidney cancer that originates in the lining of the proximal convoluted tubule , a part of the very small tubes in the kidney that transport primary urine. Initial treatment is most commonly either partial or complete removal of the affected kidney s. The body is remarkably good at hiding the symptoms and as a result people with RCC often have advanced disease by the time it is discovered. Historically, medical practitioners expected a person to present with three findings. This classic triad [8] is 1: haematuria , which is when there is blood present in the urine, 2: flank pain, which is pain on the side of the body between the hip and ribs, and 3: an abdominal mass, similar to bloating but larger. Finally, studies have found that women who have had a hysterectomy are at more than double the risk of developing RCC than those who have not. Hereditary factors have a minor impact on individual susceptibility with immediate relatives of people with RCC having a two to fourfold increased risk of developing the condition.



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If detected early, RCC is curable by surgery although a minority are at risk of recurrence. Increasing incidental detection and an ageing population has led to active surveillance as an option for patients with small renal masses. RCC is heterogeneous and comprises several histological cell types with different genetics, biology and behavior. The identification of the genes predisposing to inherited syndromes with RCC has provided much of our knowledge of the molecular basis of early sporadic RCC. Many of the oncogenes and tumor suppressor genes that are mutated leading to pathway dysregulation in RCC remain to be elucidated.

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